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Electrotherapy is a new type of Biomedical Engineering which can be used as electrochemotherapy, eradication of tumor, or intracellular electromanipulation respectively [1,2]. The biological basis of electrochemotherapy is the combination of reversal of the membrane by electroincorporation by using a weak intensity electrical pulse lasting microseconds, in conjunction with a better absorption of substances, such as Bleomycin and cisplatin for its cytotoxicity [3]. Moreover, irreversible membrane electroincorporation, being different from electrochemotherapy, is induced by intensive electrical microsecond pulses of energy and can be used alone to implement the eradication of tumors directly without any cytotoxic drugs [4-6]. Another technique is called electrical pulses per nanosecond, diminishes its effect on the plasma membrane and requires a power supply in multiple subcellular structures, known as intracellular electromanipulation and can be used in cancer treatment, gene therapy or wound healing [7]. Therefore, the electric field has different parameters that relate to biophysical effects. However, considering the our knowledge, few researchers have involved any information about the biophysical effects regarding the application of electric pulses combined durations of microseconds and nanoseconds in the treatment of cancer.

Introduction  InterferentialCurrent   LowAmplitudeFrequencyVariation  GalvanicStimulation TranscutaneousElectricalNerveStimulation 

Referencias

1 Weaver JC: Electroporation of biological membranes from multicellular to nano scales.

ITDEI 2003, 10:754-768. Publisher Full Text

2 Weaver JC: Electroporation: a general phenomenon for manipulating cells and tissues.

J Cell Biochem 1993, 51:426-435. PubMed Abstract

3 Gothelf A, Mir LM, Gehl J: Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation.

Cancer Treat Rev 2003, 29:371-387. PubMed Abstract | Publisher Full Text

4 Davalos RV, Mir IL, Rubinsky B: Tissue ablation with irreversible electroporation.

Ann Biomed Eng 2005, 33:223-231. PubMed Abstract | Publisher Full Text

5 Edd JF, Horowitz L, Davalos RV, Mir LM, Rubinsky B: In vivo results of a new focal tissue ablation technique: irreversible electroporation.

IEEE Trans Biomed Eng 2006, 53:1409-1415. PubMed Abstract | Publisher Full Text

6 Rubinsky B: Irreversible electroporation in medicine.

Technol Cancer Res Treat 2007, 6:255-260. PubMed Abstract | Publisher Full Text

7 Schoenbach KH, Hargrave B, Joshi RP, Kolb JF, Nuccitelli R, Osgood C, Pakhomov A, Stacey M, Swanson RJ, White JA, et al.: Bioelectric effects of intense nanosecond pulses.

ITDEI 2007, 14:1088-1109. Publisher Full Text

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